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Cyclobenzaprine Hydrochloride

Reference Number: AA-04117 Created: 05/27/2020 05:23 PM Last Updated: 09/11/2020 04:25 PM

Method Conditions:
Column: Cogent RP C18™, 5μm, 100Å
Catalog No.: 68518-15P
Dimensions: 4.6 x 150 mm
Buffer: Add 3.7 mL of methanesulfonic acid per 1 L of water and adjust with diethylamine to a pH of 3.6

Mobile Phase: Acetonitrile, methanol, and Buffer (25.5:21.0:53.5)

Injection vol.: 20μL

Flow rate: 1.5 mL/min

Detection: 290 nm

Diluent: Acetonitrile and water (50:50)

Standard solution: 0.12 mg/mL of USP Cyclobenzaprine Hydrochloride RS in Diluent

Peaks: 1. Cyclobenzaprine Hydrochloride

Discussion: This method demonstrates the USP Cyclobenzaprine Hydrochloride Extended-Release Capsules Assay in the Cogent RP C18. As shown in the chromatograms, the peak efficiency is superb and USP peak tailing guidelines are easily met with the Cogent RP C18 5μm column. This demonstrates a great alternative column for easy plug and play methods. The Cogent C18 is end-capped and has excellent reproducibility and robustness.

Most Recently Appeared In:
Pharmacopeial Forum: Volume No. 40(4)
Page Information:
USP42-NF37 - 1177
USP41-NF36 - 1119
USP40-NF35 - 3602

Note: Cyclobenzaprine is a muscle relaxant and works by blocking nerve impulses that signal pain sensations sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to relieve muscle spasms caused by painful conditions such as an injury.

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