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Activity in HPLC. Simple and easy definition.

Reference Number: AA-03972 Created: 04/14/2020 12:58 PM Last Updated: 09/19/2020 10:19 AM

It is the relative strength of the surface of the stationary phase in adsorption chromatography.  In the case of silica gel, the more silanol groups are available on the surface, the more active it is.  One can modifty activity by adding water or other polar solvent that will bond to active sites, reducing activity.  

Cogent TYPE-C HPLC Columns have very low activity due to the absence of silanol groups on the surface.

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